Publications

2020

  • Guido PaciniIlona DunkelNorbert MagesVerena MutzelBernd TimmermannAnnalisa
    Marsico
    and Edda G. Schulz (2020) Integrated analysis of Xist upregulation and gene silencing at the onset of random X-chromosome inactivation at high temporal and allelic resolution. bioRxiv preprint, version posted July 21. doi: https://doi.org/10.1101/2020.07.20.211573.
  • Mattia ConteLuca FiorilloSimona BiancoAndrea M. ChiarielloAndrea Esposito and Mario Nicodemi (2020) Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation. Nat Commun. Jul 3;11(1):3289. doi: 10.1038/s41467-020-17141-4. Pubmed
  • Jack E. FelthamShidong XiStruan C. MurrayMeredith WoutersJulian Urdiain-ArraizaRaphael HeiligCharlotte GeorgeAnna F. TownleyEmile RobertsBenedikt M. KesslerSabrina LiberatoriPhilip D. CharlesAndrew AngelRoman Fischer and Jane Mellor (2020) Transcriptional changes are regulated by metabolic pathway dynamics but decoupled from protein levels.
    bioRxiv preprint, version posted June 10. doi: https://doi.org/10.1101/833921.
  • Verena Mutzel and Edda G. Schulz (2020) Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X-Chromosome Inactivation. Bioessays. Apr;42(4):e1900163. doi: 10.1002/bies.201900163. Pubmed

2019

  • Lisa Barros de Andrade E SousaIris JonkersLaurène SyxIlona DunkelJulie ChaumeilChristel PicardBenjamin ForetChong-Jian ChenJohn T Lis*Edith Heard*, Edda G Schulz* and Annalisa Marsico* (2019) Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features. Genome Res. Jul;29(7):1087-1099. doi: 10.1101/gr.245027.118. Epub 2019 Jun 7.
    (* corresponding authors)
    Pubmed
  • Gaetano Ivan DellinoFernando PalluzziAndrea Maria ChiarielloRossana PiccioniSimona BiancoLaura FuriaGiulia De ContiBritta A. M. BouwmanGiorgio MelloniDavide GuidoLuciano GiacòLucilla LuziDavide CittaroMario FarettaMario NicodemiNicola Crosetto and Pier Giuseppe Pelicci (2019) Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations. Nat Genet. Jun;51(6):1011-1023. doi: 10.1038/s41588-019-0421-z. Epub 2019 May 20. Pubmed
  • Verena MutzelIkuhiro OkamotoIlona DunkelMitinori SaitouLuca GiorgettiEdith Heard and Edda G Schulz (2019) A symmetric toggle switch explains the onset of random X inactivation in different mammals. Nat Struct Mol Biol. May;26(5):350-360.
    doi: 10.1038/s41594-019-0214-1. Epub 2019 Apr 8. Pubmed
  • Kim Sneppen and Leonie Ringrose (2019) Theoretical Analysis of Polycomb-Trithorax Systems Predicts That Poised Chromatin Is Bistable and Not Bivalent. Nat Commun. May 13;10(1):2133.doi: 10.1038/s41467-019-10130-2. Pubmed

2018

  • Thomas BrownFrançoise S. HoweStruan C. MurrayMeredith WoutersPhilipp LorenzEmily SewardScott RataAndrew Angeland  Jane Mellor(2018) Antisense transcription-dependent chromatin signature modulates sense transcript dynamics. Mol Syst Biol. Feb 12;14(2):e8007. doi: 10.15252/msb.20178007. Pubmed